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In vivo applications / Monitoring
CaloBox - Indirect Calorimeter
Common applications are: Animal metabolism, nutrition, heat regulation, thermoregulation, bioenergetics, activity, animal behavior, energy balance, resting metabolic rate, energetics of locomotion, and many more. The Calobox automatically measures and calculates typical indirect calorimetry parameters such as metabolic rate, energy expenditure (EE), and respiratory exchange ratio (RER).
Functionality
- Internal pumps for air flow through animal cuvette 30..150 L/h
- Down to 4 sec reliable measurement interval
- No drying of sample or reference air required
- Measurement of O2 , CO2, and water vapor content in sample air; Comparison to reference air
- Automatic adjustment of gas sensors with reference air in preset intervals (zero adjustment)
Calculation of metabolic rates
- O2 consumption per unit time (V′O2 )
- Carbon dioxide production (V′CO2 )
- Water vapor evaporation (V′H2O)
- Respiratory exchange ratio (RER, RQ)
Calculates energy expenditure (EE) based on V′O2 and RER.
Specifications
- Dimensions: 35 x 30 x 15.8 cm
- Weight. 3.5 kg
- Mass flowmeter for sample air / Response time / Repeatability: 0...5 sLpm (0….300 L/h) / 60 msec / +- 0.5%
- Electrochemical O2-cell. Range / response time / accuracy: 0….25 Vol% / 12 sec / <1% @ 21 Vol%
- CO2 measurement, NDIR-cell (non dispersive infrared): range / response time / accuracy: 0...0.5 Vol% / 20sec / +-30 ppm
- HT-Sensor, relative humidity resolution / temperature sensor resolution: 0.025% / 0.04°C
- Thermocouple Type T, Cu-Const, resolution: +/- 0.1 °C
- Membrane pumps: longlife with brushless dc motor
References
Harding, C.D., Walker, K.M.M., Hackett, T.D. et al. Ultrasonic vocalisation rate tracks the diurnal pattern of activity in winter phenotype Djungarian hamsters (Phodopus sungorus). J Comp Physiol B (2024). https://doi.org/10.1007/s00360-024-01556-2
van der Vinne, V., McKillop, L.E., Wilcox, S.L. et al. Methods to estimate body temperature and energy expenditure dynamics in fed and fasted laboratory mice: effects of sleep deprivation and light exposure. J Comp Physiol B (2024). https://doi.org/10.1007/s00360-024-01554-4
Elfers, K., Armbrecht, Y., Brede, M., Mazzuoli-Weber, G., Heldmaier, G., Breves, G. (2022). How much does it cost? Teaching physiology of energy metabolism in mice using an indirect calorimetry system in a practical course for veterinary students. Adv Physiol Educ, 46: 145-157
Wellbrock, A. H. J., Eckhardt, L. R. H., Kelsey, N. A., Heldmaier, G., Rozman, J., Witte, K. (2022). Cool birds: first evidence of energy-saving nocturnal torpor in free-living commonswifts Apus apus resting in their nests. Biol Lett, 18: 20210675
Yamagata, T., Kahn, M. C., Prius-Mengual, J., Meijer, E., … & Vyazovskiy, V. V. (2021). The hypothalamic link between arousal and sleep homeostasis in mice. PNAS, 118(51), e2101580118.
Oelkrug, R., Krause, C., Herrmann, B., Resch, J., Gachkar, S., El Gammal, A. T., … & Mittag, J. (2020). Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring. Cell Reports, 33(5), 108351.
Martire, V. L., Berteotti, C., Bastianini, S., Alvente, S., Valli, A., Cerri, M., … & Zoccoli, G. (2020). The physiological signature of daily torpor is not orexin dependent. J Comp Physiol B.; 190(4):493-507.
Johann, K., Cremer, A. L., Fischer, A. W., Heine, M., Pensado, E. R., Resch, J., … & Astiz, M. (2019). Thyroid-hormone-induced browning of white adipose tissue does not contribute to thermogenesis and glucose consumption. Cell reports, 27(11), 3385-3400.
Descriptions
Functionality
- Internal pumps for air flow through animal cuvette 30..150 L/h
- Down to 4 sec reliable measurement interval
- No drying of sample or reference air required
- Measurement of O2 , CO2, and water vapor content in sample air; Comparison to reference air
- Automatic adjustment of gas sensors with reference air in preset intervals (zero adjustment)
Calculation of metabolic rates
- O2 consumption per unit time (V′O2 )
- Carbon dioxide production (V′CO2 )
- Water vapor evaporation (V′H2O)
- Respiratory exchange ratio (RER, RQ)
Calculates energy expenditure (EE) based on V′O2 and RER.
Specifications
- Dimensions: 35 x 30 x 15.8 cm
- Weight. 3.5 kg
- Mass flowmeter for sample air / Response time / Repeatability: 0...5 sLpm (0….300 L/h) / 60 msec / +- 0.5%
- Electrochemical O2-cell. Range / response time / accuracy: 0….25 Vol% / 12 sec / <1% @ 21 Vol%
- CO2 measurement, NDIR-cell (non dispersive infrared): range / response time / accuracy: 0...0.5 Vol% / 20sec / +-30 ppm
- HT-Sensor, relative humidity resolution / temperature sensor resolution: 0.025% / 0.04°C
- Thermocouple Type T, Cu-Const, resolution: +/- 0.1 °C
- Membrane pumps: longlife with brushless dc motor
References
Harding, C.D., Walker, K.M.M., Hackett, T.D. et al. Ultrasonic vocalisation rate tracks the diurnal pattern of activity in winter phenotype Djungarian hamsters (Phodopus sungorus). J Comp Physiol B (2024). https://doi.org/10.1007/s00360-024-01556-2
van der Vinne, V., McKillop, L.E., Wilcox, S.L. et al. Methods to estimate body temperature and energy expenditure dynamics in fed and fasted laboratory mice: effects of sleep deprivation and light exposure. J Comp Physiol B (2024). https://doi.org/10.1007/s00360-024-01554-4
Elfers, K., Armbrecht, Y., Brede, M., Mazzuoli-Weber, G., Heldmaier, G., Breves, G. (2022). How much does it cost? Teaching physiology of energy metabolism in mice using an indirect calorimetry system in a practical course for veterinary students. Adv Physiol Educ, 46: 145-157
Wellbrock, A. H. J., Eckhardt, L. R. H., Kelsey, N. A., Heldmaier, G., Rozman, J., Witte, K. (2022). Cool birds: first evidence of energy-saving nocturnal torpor in free-living commonswifts Apus apus resting in their nests. Biol Lett, 18: 20210675
Yamagata, T., Kahn, M. C., Prius-Mengual, J., Meijer, E., … & Vyazovskiy, V. V. (2021). The hypothalamic link between arousal and sleep homeostasis in mice. PNAS, 118(51), e2101580118.
Oelkrug, R., Krause, C., Herrmann, B., Resch, J., Gachkar, S., El Gammal, A. T., … & Mittag, J. (2020). Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring. Cell Reports, 33(5), 108351.
Martire, V. L., Berteotti, C., Bastianini, S., Alvente, S., Valli, A., Cerri, M., … & Zoccoli, G. (2020). The physiological signature of daily torpor is not orexin dependent. J Comp Physiol B.; 190(4):493-507.
Johann, K., Cremer, A. L., Fischer, A. W., Heine, M., Pensado, E. R., Resch, J., … & Astiz, M. (2019). Thyroid-hormone-induced browning of white adipose tissue does not contribute to thermogenesis and glucose consumption. Cell reports, 27(11), 3385-3400.
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