In our News post this week, we recommend reading this detailed review article on the current techniques for investigating the brain extracellular space. In this paper, Tønnesen’s lab provides an introduction to in vitro and in vivo current neuroscience lab methods such as point-source diffusion measurement, electron microscopy, magnetic resonance imaging, widefield fluorescence microscopy, scanning fluorescence microscopy, and super-resolution fluorescence microscopy. These techniques are mainly based on optical imaging and electrical recordings.

This multiplication of methods has offered scientists the opportunity to diversify their approach to a specific scientific question. This article highlights the strengths and weaknesses of each technology. In order to diversify the observations of a given sample, the authors recommend combining several levels of study and methodology to broaden the project perspectives.

Overview of the Current Techniques for Investigating the Brain Extracellular Space - Soria et al.