Welcome to #NeuroRigBuilder!

Javascript is disabled!

Our site was designed and built for using JavaScript technology.
For full functionality of this site it is necessary to enable JavaScript.
Here are the instructions how to do it in your web browser.

The #NeuroRigBuilder Team

New red-shifted sensors to image dopamine release in the brain
https://www.neurorigbuilder.com #NeuroRigBuilder


Dopamine is a neurotransmitter involved in key functions of the brain, e.g. motor control, reward, arousal, or motivation. To better understand the modulation of dopamine, it is fundamental to benefit from tools allowing both the manipulation of neuronal circuits and the recording of fluorescent signals in the brain, particularly in freely moving animals.

To perform such experiments, it is recommended that optogenetic actuators and imaging sensors spectra do not overlap. Therefore, expanding the fluorescent indicators palette is the key to successful multi-color imaging experiments.

In this new Nature Method article, Patriarchi et al. designed yellow-shifted and red-shifted dopamine sensors. Following their development of dLight1, a green fluorescent protein-based DA sensor, the team created YdLight1 – 525nm emission peak - and RdLight1 – 588nm emission peak. Exciting work!

Dopamine Pathways. In the brain, dopamine plays an important role in the regulation of reward and movement. As part of the reward pathway, dopamine is manufactured in nerve cell bodies located within the ventral tegmental area (VTA) and is released in the nucleus accumbens and the prefrontal cortex. Its motor functions are linked to a separate pathway, with cell bodies in the substantia nigra that manufacture and release dopamine into the striatum.


More information can be found following this link: https://doi.org/10.1038/s41592-020-0936-3.

All images shown are for illustration purpose only. See details in Terms.
https://www.neurorigbuilder.com #NeuroRigBuilder