Laser Speckle Contrast Imaging System RFLSI ZW

Scope of delivery: the main unit, a desktop computer, its peripherals, a monitor and a stand.

Technical parameters:

More features

• Equipped with calibration block for quick and regular calibration;
• Equipped with signal input and output interfaces, which can realize signal synchronization with external equipment;
• The distance is automatically measured and displayed in real time;
• Scalable TR-LSCI module (coming soon)；
• Scalable blood oxygen measurement module (coming soon);

Applications

A selection of RWD Laser Speckle Imaging System customers:

A collection of related publications:

[1] Chen J , Wang L , Xu H , et al. Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage[J]. Nature Communications, 2020, 11(1).

[2] Long C , Liu M , Tian H , et al. Potential Role of Platelet-Activating C-Type Lectin-Like Proteins in Viper Envenomation Induced Thrombotic Microangiopathy Symptom[J]. Toxins, 2020, 12(12):749.

[3] R Li, Shen Y , Li X , et al. Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome after Cardiac Arrest and Resuscitation in Young and Aged Mice[J]. Shock, 2021, publish ahead of print.

[4] Shen C , Liu M , Xu R , et al. The 14-3-3ζ–c-Src–integrin-β3 complex is vital for platelet activation[J]. Blood, 2020.

[5] Yu J , Liu Q , Li X , et al. Oxymatrine Improves the Integrity of the Blood-Brain Barrier after Cerebral Ischemia-Reperfusion Injury through the Caveolin-1/MMP-9 Signaling Pathway. 2020.

[6] Wang S , Lv W , Zhang H , et al. Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats[J]. GeroScience, 2020.

[7]Tian, Liu, Li, et al. Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri Venoms[J]. Toxins, 2020, 12(2):105.

[8] Guo Y Z , Ma Y M , Zhang X P , et al. Region-specific changes in aquaporin 4 induced by hyperglycemia underlie the differences in cell swelling in the cortex and striatum after cerebral ischemia-reperfusion[J]. Neuroscience Letters, 754.

[9]Jiao, Yue, Xin-Shang, et al. Activation of G-Protein-Coupled Receptor 30 Protects Neurons against Excitotoxicity through Inhibiting Excessive Autophagy Induced by Glutamate.[J]. ACS chemical neuroscience, 2019, 10(10):4227-4236.

[10] Guo X , Tian Y , Yang Y , et al. Pituitary Adenylate Cyclase-Activating Polypeptide Protects Against Cognitive Impairment Caused by Chronic Cerebral Hypoperfusion[J]. Molecular Neurobiology, 2021:1-14.

[11] Xu K , Gao X , Xia G , et al. Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn[J]. Gut, 2021, 70(8):gutjnl-2020-323263.

[12] X Zhu, Chen Y , X Xu, et al. SP6616 as a Kv2.1 inhibitor efficiently ameliorates peripheral neuropathy in diabetic mice[J]. EBioMedicine, 2020, 61:103061.

[13] Xu X , Wang W , Wang Z , et al. DW14006 as a Direct AMPKα Activator Ameliorates Diabetic Peripheral Neuropathy in Mice[J]. Diabetes, 2020, 69(9):db191084.

[14] Wu Y , Zeng J , Pluimer B , et al. Microvascular Injury in Mild Traumatic Brain Injury Accelerates Alzheimer-like Pathogenesis in Mice. 2020.

[15] Ma Q , Liu D , Gong R , et al. Mechanically Induced Vasospasm〦valuation of Spasmolytic Efficacy of 10 Pharmaceutical Agents Using Laser Speckle Contrast Imaging[J]. Lasers in Surgery and Medicine, 2020(5).

[16] Cong R , Sun L , Yang J , et al. Protein O-GlcNAcylation alleviates small intestinal injury induced by ischemia-reperfusion and oxygen-glucose deprivation[J]. Biomedicine & Pharmacotherapy, 2021, 138(5):111477.

[17] Fang F , Liu M , Xiao J , et al. Arterial Supercharging Is More Beneficial to Flap Survival Due to Quadruple Dilation of Venules[J]. Journal of Surgical Research, 2019, 247.

[18] Xu B , Xu J , Cai N , et al. Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway[J]. Free Radical Biology and Medicine, 2020, 163.

[19]Wang W, Li R, Miao W, Evans C, Lu L, Lyu J, Li X, Warner DS, Zhong X, Hoffmann U, Sheng H, Yang W. Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired

Lymphopoiesis After Resuscitation. J Am Heart Assoc. 2021 Jun;10(11):e019142. doi: 10.1161/JAHA.120.019142. Epub 2021 May 20. PMID: 34013738; PMCID: PMC8483518.

[20]Zaidi SK, Ahmed F, Alkhatabi H, Hoda MN, Al-Qahtani M. Nebulization of Low-Dose S-Nitrosoglutathione in Diabetic Stroke Enhances Benefits of Reperfusion and Prevents Post-Thrombolysis Hemorrhage. Biomolecules. 2021 Oct 27;11(11):1587.

 doi: 10.3390/biom11111587. PMID: 34827584; PMCID: PMC8615482.

[21]Li H, Yang Z, Tang Q, Shi Z, Mao Y. Embolic Stroke Model with Magnetic Nanoparticles. ACS Appl Mater Interfaces. 2021 Sep 22;13(37):43993-44001. doi: 10.1021/acsami.1c11377. Epub 2021 Sep 8. PMID: 34495626.

[22] Yu W ,  Yin N ,  Yang Y , et al. Rescuing Ischemic Stroke by Biomimetic Nanovesicles through Accelerated Thrombolysis and Sequential Ischemia-Reperfusion Protection.  2021.

[23]Extracellular vesicles from adipose-derived stem cells promote microglia M2 polarization and neurological recovery in a mouse model of transient middle cerebral artery occlusion[J]. Stem Cell Research & Therapy, 2022, 13(1):1-17.

[24]Jin, Yuxiao, et al. "Precise control of embolic stroke with magnetized red blood cells in mice." Communications biology 5.1 (2022): 1-12.

[25]Fu X, Zhang T, Lin W, et al. Establishment of a hypoxia ischemia reperfusion brain damage model in neonatal rats[J]. bioRxiv, 2022: 2022.01. 10.475606.

[26]Liu M, Luo L, Fu J, et al. Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis[J]. Experimental Neurology, 2022, 349: 113952.

[27]Wu Y, Tang X, Lee S, et al. Endothelial PPARδ facilitates the post-ischemic vascular repair through interaction with HIF1α[J]. Theranostics, 2022, 12(4): 1855.

[28]Wang F, Wang Q, Wang L, et al. Low-intensity focused ultrasound stimulation ameliorates working memory dysfunctions in vascular dementia rats via improving neuronal environment[J]. Frontiers in aging neuroscience, 2022, 14.

[29]Lin W, Zhang T, Zheng J, et al. Ferroptosis is Involved in Hypoxic-ischemic Brain Damage in Neonatal Rats[J]. Neuroscience, 2022, 487: 131-142.

[30]Deng L D, Qi L, Suo Q, et al. Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice[J]. Neural Regeneration Research, 2022, 17(9): 2058.

[31]Jiang W, Zhang P, Yang P, et al. Phosphoproteome Analysis Identifies a Synaptotagmin-1-Associated Complex Involved in Ischemic Neuron Injury[J]. Molecular & Cellular Proteomics, 2022, 21(5).

[32]Yang Y, Tian Y, Guo X, Li S, Wang W, Shi J. Ischemia Injury induces mPTP opening by reducing Sirt3. Neuroscience. 2021 Aug 1;468:68-74. doi: 10.1016/j.neuroscience.2021.06.003. Epub 2021 Jun 11. PMID: 34119577.

[33]Tian, Liu, Li, et al. Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri Venoms[J]. Toxins, 2020, 12(2):105.

[34]Duan W, Sun Q, Wu X, et al. Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy[J]. Neuromodulation: Technology at the Neural Interface, 2022, 25(3): 414-423.

[35] Lu Y A ,  Yt A ,  Ll A , et al. Dengzhan Xixin injection derived from a traditional Chinese herb [36] Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis.  2022.

Wan T, Zhu W, Zhao Y, et al. Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice[J]. Nature communications, 2022, 13(1): 1-18.

[37]Li X, Li H, Xu Z, et al. Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons[J]. Cell Death & Disease, 2022, 13(4): 1-14.

[38]Zang J, Tang X, Su X, et al. Systematic Analysis of RNA Expression Profiles in Different Ischemic Cortices in MCAO Mice[J]. Cellular and Molecular Neurobiology, 2022: 1-20.

[39]Yang Y, Li Y, Pan Q, et al. Tibial cortex transverse transport accelerates wound healing via enhanced angiogenesis and immunomodulation[J]. Bone & Joint Research, 2022, 11(4): 189-199.

[40]Li Y, Liu Z, Song Y, et al. M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice[J]. Theranostics, 2022, 12(7): 3553-3573.

[41]Wu Y, Lin X, Hong H, et al. Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice[J]. Biomedicine & Pharmacotherapy, 2022, 151: 113172.

[42]Tedeschi A, Larson M J E, Zouridakis A, et al. Harnessing cortical plasticity via gabapentinoid administration promotes recovery after stroke[J]. Brain, 2022.

[43]Liu M, Zhou X, Li Y, et al. TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner[J]. Redox Biology, 2022, 53: 102323.

[43]Fan L, Chen Y, Liao R, et al. Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia[J]. Acta Pharmacologica Sinica, 2022: 1-10.

[44]Cai N, Xu B, Li X, et al. Roflumilast, a cyclic nucleotide phosphodiesterase 4 inhibitor, protects against cerebrovascular endothelial injury following cerebral ischemia/reperfusion by activating the Notch1/Hes1 pathway[J]. European Journal of Pharmacology, 2022: 175027.

[45]Song M M, Chen J, Ye S M, et al. Targeted delivery of edaravone by liposomes for the treatment of ischemic stroke[J]. Nanomedicine, 2022 (0).

[46]Zhou Y, Huang D, Cai Y, et al. lncRNA DHFRL1‑4 knockdown attenuates cerebral ischemia/reperfusion injury by upregulating the levels of angiogenesis‑related genes[J]. International Journal of Molecular Medicine, 2022, 50(2): 1-10.

[47]Zhou Y, Huang D, Cai Y, et al. lncRNA DHFRL1‑4 knockdown attenuates cerebral ischemia/reperfusion injury by upregulating the levels of angiogenesis‑related genes[J]. International Journal of Molecular Medicine, 2022, 50(2): 1-10.

[48]Pan L, Tang W, Wang K, et al. Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window[J]. Acta Pharmacologica Sinica, 2022: 1-11.

[49]Moreno M, Minjarez C, Vigil J, et al. Differences in hippocampal plasticity and memory outcomes in anterior versus posterior cerebellar stroke[J]. Neurobiology of Disease, 2022, 168: 105701.

[50]Shi H, Li P, Zhou H, et al. Dynamic cerebral blood flow changes with FOXOs stimulation are involved in neuronal damage associated with high-altitude cerebral edema in mice[J]. Brain Research, 2022: 147987.

[50]Qing H, Wang Z, Li R, et al. M2 macrophage-derived exosomes for DNase 1 delivery to modulate inflammatory microenvironment in ischemic stroke[J]. 2022.

[51]Zhang Y, Mu Y, Ding H, et al. 1α, 25-Dihydroxyvitamin D3 Promotes Angiogenesis After Cerebral Ischemia Injury in Rats by Upregulating the TGF-β/Smad2/3 Signaling Pathway[J]. Frontiers in cardiovascular medicine, 2022, 9.

[52]Wang C, Yang X, Jiang Y, et al. Targeted delivery of fat extract by platelet membrane-cloaked nanocarriers for the treatment of ischemic stroke[J]. Journal of Nanobiotechnology, 2022, 20(1): 1-20.

[53]Xie Y, Fang F, Lin P, et al. Segmental branches emanating from saphenous nerve morphing into sympathetic trunks for innervation of saphenous artery and its clinical implication for arterial sympathectomy[J]. International Wound Journal, 2022, 19(2): 294-304.

[54]Jiang W, Zhang P, Yang P, et al. Phosphoproteome Analysis Identifies a Synaptotagmin-1-Associated Complex Involved in Ischemic Neuron Injury[J]. Molecular & Cellular Proteomics, 2022, 21(5).

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