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DNI-D-Asp-TFA 14mg 20pkg
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Chemical Compounds

DNI-D-Asp-TFA

from Femtonics

DNI-D-Asp-TFA 14mg 20pkg

20 pkgs of 14 mg unit, total 280 mg
Lead time:
Max. 8 weeks
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Description: Caged D-aspartate

Chemical Name: 4-methoxy-5,7-dinitroindolinyl-D-aspartate trifluoroacetate

Purity: ≥98% (HPLC)

 

Biological Activity for DNI-D-Asp-TFA

  1. Rapidly and efficiently releases D-Asp neurotransmitter, by the effect of one (360 nm) or two photon (720 nm) irradiation,
  2. Agonist at NMDA receptors and EAAT substrate,
  3. Exists as trifluoroacetic acid salted form, ensuring good solubility, stability and low hygroscopicity of the product,
  4. Highly resistant to hydrolysis at neutral pH,
  5. Higher quantum yield (ca. 7 times, than MNI-D-Asp ),
  6. Releases D-Asp neurotransmitter more rapidly by the effect of two photon irradiation (720 nm) than MNI-D-Asp.

 

Technical Data for DNI-D-Asp-TFA

M. Wt

468.30

Formula

C15H15N4O10F3

Storage

Store at -20°C

Purity

≥98% (HPLC)

 

Solubility Data for DNI-D-Asp-TFA

 

Solvent

Max Conc. mg/mL

Max Conc. mM

Solubility

water

10.0

21.4

 

References for DNI-D-Asp-TFA

Electrical behaviour of dendritic spines as revealed by voltage imaging Marko A. at al Nature Communications(2015)

Local Postsynaptic Voltage-Gated Sodium Channel Activation in Dendritic Spines of Olfactory Bulb Granule Cells  Wolfgang G. at al  Neuron(2015)

Spine neck plasticity regulates compartmentalization of synapses Tønnesen J. at al Nature Neuroscience (2014)

Dendritic spikes induce ripples in parvalbumin interneurons during hippocampal sharp waves. Chiovini B. at al Neuron (2014)

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Descriptions


Description: Caged D-aspartate

Chemical Name: 4-methoxy-5,7-dinitroindolinyl-D-aspartate trifluoroacetate

Purity: ≥98% (HPLC)

 

Biological Activity for DNI-D-Asp-TFA

  1. Rapidly and efficiently releases D-Asp neurotransmitter, by the effect of one (360 nm) or two photon (720 nm) irradiation,
  2. Agonist at NMDA receptors and EAAT substrate,
  3. Exists as trifluoroacetic acid salted form, ensuring good solubility, stability and low hygroscopicity of the product,
  4. Highly resistant to hydrolysis at neutral pH,
  5. Higher quantum yield (ca. 7 times, than MNI-D-Asp ),
  6. Releases D-Asp neurotransmitter more rapidly by the effect of two photon irradiation (720 nm) than MNI-D-Asp.

 

Technical Data for DNI-D-Asp-TFA

M. Wt

468.30

Formula

C15H15N4O10F3

Storage

Store at -20°C

Purity

≥98% (HPLC)

 

Solubility Data for DNI-D-Asp-TFA

 

Solvent

Max Conc. mg/mL

Max Conc. mM

Solubility

water

10.0

21.4

 

References for DNI-D-Asp-TFA

Electrical behaviour of dendritic spines as revealed by voltage imaging Marko A. at al Nature Communications(2015)

Local Postsynaptic Voltage-Gated Sodium Channel Activation in Dendritic Spines of Olfactory Bulb Granule Cells  Wolfgang G. at al  Neuron(2015)

Spine neck plasticity regulates compartmentalization of synapses Tønnesen J. at al Nature Neuroscience (2014)

Dendritic spikes induce ripples in parvalbumin interneurons during hippocampal sharp waves. Chiovini B. at al Neuron (2014)


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