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PhenoSys was founded in 2006 and is an R&D company based in the centre of Berlin in Germany. They engineer and market innovative technology for animal behaviour research.
They offer high-end systems for behavioural phenotyping, brain research, experimental psychology, and the diagnostic characterization of animal models for translational medicine.
This company is doing neuroscience-engineering as a mission! Check out their unique solutions for VR and MORE on #NeuroRigBuilder!
New study “Reward Association Enhances Stimulus-Specific Representations in Primary Visual Cortex.” has been recently released last month in Current Biology. Henschke and her colleagues demonstrated that the association of a reward with a repetitive visual stimulus over 5 consecutive days resulted in an enhanced representation of the reward-associated stimulus in mouse V1 layer 2/3 neurons, while responses to other stimuli were unaffected. They did sophisticated behavior experiments like random, uncoupled and goal-oriented water reward with VR system during locomotion in a learning paradigm.
They performed two-photon resonant calcium imaging and used Jet Ball System from #PhenoSys.
The study is open access: https://www.cell.com/current-biology/pdf/S0960-9822(20)30356-0.pdf
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During these difficult days, an interesting scientific breaktrough feels just like a good mojito cocktail on the beach. People around the world are focusing on Covid-19 and watching how the virus is spreading everywhere. Everybody knows a virus can infect people but there is something else too. The nervous system can also transmit mRNA between cells like a virus! Retrovirus Gag (group-specific antigen gene) polyprotein mediates capsid formation to pack and transfer viral genomes into the cytoplasm of newly infected cells. Two teams (Pastuzyn et al., 2018; Ashley et al., 2018) used single-particle cryo-electron microscopy to visualize the viral capsids. They presented a high-resolution structural representation of Arc (activity-regulated cytoskeleton-associated protein) capsids, enabling deeper analysis of their function. Source: Pastuzyn, E. D. et al. Cell 172, 275–288.e18 (2018). , Ashley, J. et al. Cell 172, 262–274.e11 (2018) |
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The most important tool in neuroscience is a multiphoton rig in 2020. If we ask why, the answer is relatively easy, because it is non-invasive and it is able to use for functional imaging. In a recent study Wang and his colleagues showed a new method to examine the mouse without any surgery. They could image the cortex with a decent spatial resolution even in the deep regions. Three-photon excitation (3PE) is a great tool to revolutionize the functional imaging in the neuroscience. The attached figure shows a comparison of through-skull vasculature imaging by 3PM and 2PM. Original publication: Wang, T., Ouzounov, D.G., Wu, C. et al. Three-photon imaging of mouse brain structure and function through the intact skull. Nat Methods 15, 789–792 (2018) |
Femto-Gramophone is an affordable, single-dimension VR system allowing a head restrained mouse to respond to visual or to other stimuli by controlling its speed on a rotating disk.
Femtonics has tremendous experience in the in vivo head-restrained experimentation. They developed their own solution for head fixation by introducing a mobile device that is easy to adjust under the objective. The simplicity of the apparatus is the most attempting for 2p researchers.
As you first fixed the mice with a two-point head holder outside of the shading box. If it is necessary the height of the holder is adjustable.
The Gramophone can have an exact place under the microscope, therefore you will only need to fine adjustment to locate the cranial window under the objective by using the camera image and the XY positioner of your microscope.
If you would like to know more about the Gramophone and how it is combined with a VR system please check on: Gramophone Complete System
Femtonics is one of the most innovative companies in the multiphoton market having slogan "THINKING AHEAD", a uniques approach has been chosen from the very beginning.
Femtonics was founded by two scientists as a spin-off R&D company with roots in the Institute of Experimental Medicine of the Hungarian Academy of Sciences. Since then, they have expanded into a multidisciplinary team to bring research tools to labs which lead to great, novel scientific findings.
Their dedication to discovering new technologies is uncomparable. They always try to be the first to develop cutting edge techniques of high value-added 3D and modular laser scanning microscopes. The company is really proud of its reputation ( 120+ microscopes sold worldwide, 300 satisfied users, and 130+ publications ) and we need to highlight most of their systems are custom built for a specific need.
Femtonics is most known for its engineering team, which made a complex research tool (acousto-optical deflector based scanning microscopy ) to an outstanding commercially available product.
They are currently represented with their behavioral device the Grampohone and some accessories such as a customizable shading box on the NeuroRigBuilder. More and more products are coming from Femtonics to #NeuroRigBuilder.
Visit us and shop the science!
Supertech Instruments designs and manufactures measuring equipment for physiological, biological, pharmacological, neuroscience, and brain research applications.
Supertech has provided high quality, well-engineered, cost-effective products to the neuroscience community since 1991. Supertech Instruments electronic products have an exceptionally low fault rate. The team is quite proud of that, therefore they offer a long default warranty period on their products.
You will find plenty of products from Supertech on our site, which will help your research.
